A research team in Japan has developed a biohybrid approach that works inside the body, transforming engineered skin to a visible indicator of internal biological states, according to WAM News Agency.

A joint research group, led by Tokyo City University and the University of Tokyo, in collaboration with RIKEN and Canon Medical Systems Co., has unveiled a living sensor display: an engineered skin graft that fluoresces in response to specific biomarkers, such as inflammation.

Reported in Nature Communications, the system leverages the body's natural skin regeneration to support long-term biomarker monitoring, providing a visual readout without blood sampling after implantation and enabling intuitive assessment by observation.

The monitoring of internal biomarkers - proteins that indicate inflammation, stress, or disease - typically relies on blood sampling or externally attached sensors that operate only for limited durations.

"Conventional approaches are often invasive or provide only snapshots in time," said Professor Hiroyuki Fujita of Tokyo City University. "Our goal was to explore a biologically integrated system that enables continuous sensing and intuitive interpretation, even at home."

To achieve this, the researchers used epidermal stem cells, which naturally maintain and renew the skin throughout life. By genetically engineering these cells to respond to inflammatory signaling - more specifically, the activation of the NF-κB pathway - the team generated skin tissue that expresses enhanced green fluorescent protein (EGFP) in response to inflammation-related signals.

When transplanted onto mice, the engineered skin engrafted and functionally integrated with the host tissue. Upon the induction of inflammation, the grafted area emitted green fluorescence, translating internal molecular signals to an external optical signal.

Because the sensor comprises living epidermal stem cells, it is maintained through the skin's natural turnover.

"Unlike conventional devices that require power sources or periodic replacement, this system is biologically maintained by the body itself," said Professor Shoji Takeuchi of the University of Tokyo. "In our experiments, the sensor functionality was preserved for over 200 days, as the engineered stem cells continuously regenerated the epidermis."

This study demonstrates a proof of concept for long-term, biologically integrated sensing without batteries, wiring, or active user operation. Although this work focused on inflammatory signaling, the underlying strategy is adaptable. By modifying the molecular targets, similar engineered skin constructs could be designed to respond to other physiological or metabolic cues.

The researchers noted that such technology could have applications beyond human healthcare, including those in animal research and veterinary medicine, where visual indicators of health status may aid the early detection of disease in animals unable to communicate symptoms.